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";s:4:"text";s:5119:"Inactivation of the CDC25 gene product in Saccharomyces cerevisiae leads to a decrease in glycolytic activity which is independent of cAMP levels. Oehlen LJ(1), Scholte ME, de Koning W, van Dam K. Author information: (1)E.C. Genomes and Genes, Research Grants, Scientific Experts, Research Topics, Publications, Species about cdc25 Genomes and Genes, Research Grants, Scientific Experts, Research Topics, Publications, Species about cdc25 Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). In the fission yeast S. pombe the cdc25 + gene function is required to initiate mitosis. Biography Dr. Pirrung is an organic chemist with research in the areas of chemical biology, synthesis, and nucleic acids. The following CDC25 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. The gene corresponding to the S. cerevisiae cell division cycle mutant cdc25 has been cloned and sequenced, revealing an open reading frame encoding a protein of 1589 amino acids that contains no significant homologies with other known proteins. ... Cdc25 Phosphatase. FULL TEXT Abstract: Genetic data suggest that the yeast cell cycle control gene CDC25 is an upstream regulator of RAS2. Asexpectedfromgenetic data, Sdc25 sequencescansubsti- How to Cite. Comparison of Thermosensitive Alleles of the CDC25 Gene Involved in the cAMP Metabolism of Saccharomyces cerevisiae Meaning of CDC gene medical term. Cdc25 is a dual-specificity phosphatase first isolated from the yeast Schizosaccharomyces pombe as a cell cycle defective mutant. Shirayama, M., Matsui, Y., Tanaka, K. and Toh-E, A. The Orysa;CDC25;1 protein is 137 aa long and displays 60% identity over 131 amino acid residues with the Arath;CDC25 protein . We have cloned the cdc25 + gene and have found that increased cdc25 + expression causes mitosis to initiate at a reduced cell size. Oncogenic potential of a C.elegans cdc25 gene is demonstrated by a gain-of-function allele. View and buy high purity products active at Cdc25 Phosphatase from Tocris Bioscience. Strausfeld et al. These sequences represent the protein The sal3 + Gene Encodes an Importin- Implicated in the Nuclear Import of Cdc25 in Schizosaccharomyces pombe The following CDC25 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). Cdc25 is involved in the DNA damage checkpoints and is known as a key mediator of cell cycle progression. Slater Institute for Biochemical Research, University of Amsterdam, The Netherlands. Two previously undescribed human cdc25 genes, designated cdc25 A and cdc25 B, which have been shown to have an endogenous tyrosine Complete information for CHEK2 gene (Protein Coding), Checkpoint Kinase 2, including: function, proteins, disorders, pathways, orthologs, and expression. CDC gene explanation free. These sequences represent the protein coding region of the CDC25 cDNA ORF which is encoded by (1994), Isolation of a CDC25 family gene, MSI2/LTE1, as a multicopy suppressor of ira1. Cell division control protein 25 ... CDC25_YEAST Accession i: P04821 ... (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD In the rice genome two CDC25-related genes were found, Orysa;CDC25;1 and Orysa;CDC25;2. 196 cdc-25 in Pinewood Nematode MATERIALS AND METHODS Isolation of Bx-cdc25 gene To isolate cdc25 gene in B. xylophilus, an EST database devel- The cdc25B gene is one of three human cdc25 homologs which can complement the temperature-sensitive cdc25 mutation of Schizosaccharomyces pombe, and is expressed a high levels in human cell lines, particularly in some cancer cells . The sal3 + Gene Encodes an Importin- Implicated in the Nuclear Import of Cdc25 in Schizosaccharomyces pombe Tyrosine protein phosphatase that dephosphorylates CDK complex and activate its kinase activity in vitro. Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - Cdc25A, B and C. Cdc25 activates cdk complexes that drive the cell cycle. Genetic linkage between the RAS2SC andSU25-3genes Ditype Genelinkage analyzed Tetratype Parental Recombinant Expt 1 RAS2(LEU2)-SU25-3 26 0 0 NOTES 2981 TABLE 1. Gould et al. Temperature-sensitive yeast mutants in Cdc25 have been shown to arrest at G2M prior to entry into mitosis. Looking for online definition of CDC gene in the Medical Dictionary? What is CDC gene? The Cdc25 gene was first characterized in the fission yeast Schizosaccharomyces pombe to be a dose-dependent inducer of mitosis (Russell and Nurse, 1986; Russell and Nurse, 1987). (1990) demonstrated that the CDC25 gene product is a protein-tyrosine phosphatase. Complete information for CDC25C gene (Protein Coding), Cell Division Cycle 25C, including: function, proteins, disorders, pathways, orthologs, and expression. described above, the carboxy-terminal half of the CDC25 gene productbinds to both Rasl and Ras2proteins in vivo. 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